MOTS-c Peptide: A Provider's Guide to Identity, Supply Format, and Access

Short answer: MOTS-c is a 16-amino-acid peptide (sequence MRWQEMGYIFYPRKLR) encoded within the mitochondrial MT-RNR1 gene, the gene for 12S ribosomal RNA. That's why it's called a mitochondrial-derived peptide. It was first described by Lee and colleagues in Cell Metabolism in 2015 (Lee et al., 2015; UniProt A0A0C5B5G6). For clinics, the MOTS-c peptide is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Biomed Peptides makes it available only to verified, licensed providers.

If your practice is getting questions about MOTS-c, or you're deciding whether to add it to your formulary, this guide covers the identity facts, the supply format, and how provider access works. It doesn't cover clinical use. That decision belongs to the prescribing clinician.

What is the MOTS-c peptide?

The name stands for mitochondrial open reading frame of the twelve S rRNA, type c. Most human proteins are encoded in nuclear DNA. MOTS-c is different: its short open reading frame sits inside the mitochondrial genome, within the 12S rRNA gene (Lee et al., 2015).

UniProt, the standard curated protein database, lists it under the recommended name "Mitochondrial-derived peptide MOTS-c." The entry records these details (UniProt A0A0C5B5G6):

Attribute	Value
Recommended name	Mitochondrial-derived peptide MOTS-c
Gene	MT-RNR1 (12S rRNA)
Length	16 amino acids
Sequence	MRWQEMGYIFYPRKLR
Organism	Homo sapiens

These identity details are useful when you read a supplier's certificate of analysis (COA). The sequence, molecular weight, and identity test on the COA should match the published sequence.

Mitochondrial-derived peptides as a class

MOTS-c belongs to a small group of peptides whose coding sequences sit in mitochondrial DNA rather than nuclear DNA. When staff or patients ask what makes it unusual, this is the accurate one-line answer: it's a peptide encoded by the mitochondrial genome. You don't need to go further than that to explain what it is.

How MOTS-c is supplied to clinics

Lyophilized vial format

Like most peptides used in clinical settings, MOTS-c comes as a lyophilized powder in a sealed, single-container vial. Freeze-drying removes most of the water that drives peptide degradation, so a dry vial holds up much better in storage and transit than a solution does (Bachem). Our lyophilized peptides guide explains the format and the reconstitution workflow for clinic staff.

The Biomed Peptides lyophilized catalog lists MOTS-c in three vial strengths (10 mg, 20 mg, and 40 mg). Pricing appears only after a provider account is approved.

Storage on receipt

Handle MOTS-c the same way as any other lyophilized peptide:

• Keep vials sealed, dry, and away from light.
• Store cold for long-term holding, and follow the label first.
• Let a cold vial reach room temperature before you open it, so condensation doesn't form on the powder.
• Limit freeze-thaw cycles.

These rules come from manufacturer handling guidance (Bachem). Our lyophilized peptides storage guide covers each one in detail.

Diluent

Lyophilized vials are reconstituted with a sterile diluent specified on the product labeling, Many clinics use bacteriostatic water. Our guide to bacteriostatic water for peptides explains what it is and when it's used.

MOTS-c peptide for sale: how provider access works

Searches like "MOTS-c peptide for sale" and "MOTS-c peptide buy online" mostly lead to consumer storefronts. Biomed Peptides works differently: we supply physician-use product only to licensed healthcare providers, and we don't sell to patients or consumers.

Here's how a practice gets access:

1. Apply. Submit the provider application with your clinic details and medical license information.
2. Verification. Our team checks your credentials, usually within 24–48 hours.
3. Portal access. Approved accounts can see the full catalog, wholesale pricing, and quality documentation.
4. Fulfillment. Order for office use or patient-specific fulfillment, with shipping to all 50 states.

Who can order and prescribe depends on licensure and state rules. Our article on who can prescribe peptides gives a general overview. Check your own state's requirements, since we don't give legal advice.

What to check before you order MOTS-c

Before you bring MOTS-c into your formulary, ask any supplier for these:

• A lot-specific COA. It should show identity (mass spectrometry), purity (HPLC), and peptide content, and the identity result should match the 16-residue sequence above.
• An endotoxin report for the lot.
• Labeled storage conditions and expiration dating.
• Cold-chain or temperature-controlled packaging where the label calls for it.

Our guide to choosing a wholesale peptide supplier explains how to evaluate this documentation. If you're comparing sourcing channels, our 503A pharmacy explainer covers how compounding pharmacies fit in.

Related catalog items

The catalog groups MOTS-c in its Longevity / Mitochondrial category alongside SS-31 and Epithalon. Each one is a separate lyophilized product with its own COA. Verify each lot independently instead of assuming documentation carries over from one product to another.

Get physician-use MOTS-c for your practice

If you're a licensed provider, med spa, or telehealth clinic, apply for provider access to see MOTS-c pricing and lot documentation, or browse the lyophilized catalog first.

FAQ

What is the MOTS-c peptide?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MRWQEMGYIFYPRKLR) encoded within the mitochondrial 12S rRNA gene, MT-RNR1. It was first described in Cell Metabolism in 2015.

What does MOTS-c stand for?

It stands for "mitochondrial open reading frame of the twelve S rRNA, type c," which refers to where its coding sequence sits in the mitochondrial genome.

How is MOTS-c supplied to clinics?

As a lyophilized (freeze-dried) powder in a sealed vial. Clinic staff reconstitute it with a sterile diluent, following the product labeling.

Where can a practice find MOTS-c peptide for sale?

Through a provider-only supplier. Biomed Peptides supplies MOTS-c only to verified licensed providers. Apply at /apply to see pricing.

Can I buy MOTS-c peptide online as a patient?

No. Biomed Peptides doesn't sell to consumers. All orders go through a licensed healthcare provider.

How should MOTS-c vials be stored?

Keep them sealed, cold, dry, and away from light, and follow the label. Let a cold vial warm to room temperature before you open it.

Sources

• Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c […]. Cell Metabolism. 2015;21(3):443–454. https://doi.org/10.1016/j.cmet.2015.02.009
• UniProt. A0A0C5B5G6 · Mitochondrial-derived peptide MOTS-c. https://www.uniprot.org/uniprotkb/A0A0C5B5G6/entry
• Bachem. Handling and Storage Guidelines for Peptides. https://www.bachem.com/knowledge-center/handling-and-storage-guidelines-for-peptides/

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